منابع مشابه
Kinetics of Tethering Quaternary Ammonium Compounds to K+ Channels
Polymeric maleimido-quaternary ammonium (QA) compounds have been shown to function as molecular tape measures when covalently tethered to external cysteine residues of a Shaker K(+) channel (Blaustein R.O., P.A. Cole, C. Williams, and C. Miller. 2000. Nat. Struct. Biol. 7:309-311). For sufficiently long compounds, the cysteine-maleimide tethering reaction creates a high concentration, at the ch...
متن کاملKv7 Channels Can Function without Constitutive Calmodulin Tethering
M-channels are voltage-gated potassium channels composed of Kv7.2-7.5 subunits that serve as important regulators of neuronal excitability. Calmodulin binding is required for Kv7 channel function and mutations in Kv7.2 that disrupt calmodulin binding cause Benign Familial Neonatal Convulsions (BFNC), a dominantly inherited human epilepsy. On the basis that Kv7.2 mutants deficient in calmodulin ...
متن کاملThe role of ATP-dependent K+ channels in antinociception, tolerance and morphine dependence
Tolerance and dependence are two main problems that have limited morphine administration as an analgesic drug and they might be as a result of changes in the number and affinity of receptors, dysfunction of adenylate cyclase, impaired coupling between activated µ receptor and K+ channels, and changes in the K+ and Ca2+ channels. There are several reports concerning the role of some of these...
متن کاملMicrobial K+ Channels
A survey of the currently available genomes shows that K channels are found in most free-living bacteria, archaea, and protists, indicating early evolution before the divergences of the three major domains of life. Though vertically descended from the primordial K channels, more recent lateral transfers of K channel genes must also have occurred. Variations in the motifs of transmembrane or cyt...
متن کامل-activated K Channels
BK channels modulate neurotransmitter release due to their activation by voltage and Ca 2 . Intracellular Mg 2 also modulates BK channels in multiple ways with opposite effects on channel function. Previous single-channel studies have shown that Mg 2 blocks the pore of BK channels in a voltage-dependent manner. We have confirmed this result by studying macroscopic currents of the mslo1 channel....
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2008
ISSN: 0021-9258
DOI: 10.1074/jbc.r800033200